This paper proposes a 2.4 GHz active mixer without passive inductor for the transceiver system. Taking into account the design requirements of the mixer, a double-balanced down-conversion structure with active inductor and negative resistance is designed. The proposed mixer with 130 nm CMOS technology is designed and simulated using Cadence software at 1.5 V supply voltage. Although we had to compromise conversion gain with linearity, we were able to achieve very High conversion gain with average linearity. Based on the results of post-layout simulations, the conversion gain of 27.57 dB, IIP3 equal to -7.88 dBm, 1-dB compression point equal to -17.34 dBm and IIP2 equal to 44.22 dBm with power consumption of 2.5 mW was obtained for the proposed mixer. The chip size without input and output pads is 95.18 µm × 117.68 µm, which leads to a chip area of 0.0112mm2.

Background and Aims: Various methods are used for treatment of open bite. The objective of this study was to investigate the effects of Lower Anterior High Pull Headgear (LAHPH) appliance in Class I subjects with moderate open bite and High lower lip line.Materials and Methods: The study group was composed of 10 subjects with a mean age of 15.8±2.5 years and 3.05±0.07 mm moderate open bite. All the patients rejected or thognathic surgery. The treatment included extraction of upper and lower second premolars followed by leveling, banding, bonding, posterior space closure, and anterior retraction. After these procedures, the open bite was reduced to 2.04±1.17 mm. afterwards; LAHPH was applied for 18 hours per day for 8±2 months. LAHPH appliance was composed of High Pull Headgear and two hooks mounted on its inner bow. Two elastics (1.8, light, Dentaurum) connected the upper hooks on the inner bow to the lower hooks on the mandibular canines vertically. The forces produced by the prescribed elastics were 10 and 60 g during mouth closing and opening, respectively. Paired T-test was used to evaluate pre-and post-treatment outcomes.Results: The pre-and post-treatment cephalometric evaluations showed that the LAHPH reduced effectively the open bite of the patients to 0.15±1.7 mm (P<0.001).Conclusion: This appliance can be used as an acceptable method for closing the open bite in Class I subjects.

Background: The High Resolution Melting (HRM) method is a new scanning method for detecting unknown changes in DNA and its advantages have persuaded researchers to recruit it as a screening method. Objectives: Here, we developed a HRM method to screen R188H SNP (rs3218536) of XRCC2 and compared the results with a well known PCRRFLP technique.Materials and Methods: Genomic DNA samples from 350 healthy individuals were obtained. PCR-HRM analysis and PCR-RFLP method were performed simultaneously.Results: Three different melting profiles corresponding to three different genotypes recognized by HRM analysis. The results of PCR-RFLP showed no discrepancy. Conclusions: We concluded that the HRM technique can be used as a screening method for rapid discrimination of R188H genotypes in XRCC2 gene.

Background and Objectives: Knee joint as the largest synovial joint in the body, consists of the lateral collateral ligament, cruciate ligament, and medial and lateral meniscus. For proper management, identification of damage to any structures of the knee is necessary. In this study, snsitivity, specificity, and diagnostic accuracy of High resolution CT scan in meniscal lesions, were assessed. Methods: In this test accuracy assessment study, 57 patients with a history of positive meniscus lesion, who referred to Ayatollah Mousavi Hospital of Zanjan city from 2015 to 2016, were investigated by magnetic resonance imaging, High resolution computed tomography, and arthroscopy. Magnetic resonance imaging and High resolution computed tomography data, were compared to knee arthroscopy as the diagnosis gold standard. Kappa (κ ) correlation coefficient was used to calculate the consistency of the tests. Results: Out of the 57 patients presented with meniscal lesion, 52 patients (91. 2%) were male and 5 patients (8. 8%) were female. The Highest incidence of meniscal lesions was in ages from 21 to 30 years. Among the causes of meniscal lesions, exercise with prevalence of 47. 9%, was the most prevalent cause of injury. In comparison with arthroscopy, the sensitivity, specificity, and accuracy of High resolution computed tomography were determined to be 64. 7%, 55%, and 60%, respectively, and for magnetic resonance imaging were 85. 2%, 50%, and 77. 5%, respectively. Conclusion: According to the results of the present study, specificity, sensitivity, and accuracy of High resolution computed tomography in the diagnosis of meniscal lesions, was lower than the previous studies.

In this paper, a new High Step-Up current-fed LLC resonant DC-DC converter with a center-tapped transformer is proposed. By selecting the switching frequency to be lower than, but near to, the series resonant frequency of the LLC resonant tank, soft-switching operation of all semiconductors, i.e., zero voltage switching (ZVS) turn-on of power MOSFETs and zero current switching (ZCS) turn-off of diodes is achieved. This leads to lower electromagnetic interference (EMI) and lower switching losses and improves the converter efficiency. An interleaved structure is used at the primary side. Thus, input current ripple is smaller, and its frequency is twice the switching frequency. Consequently, a smaller input filter is necessary in practice. The converter with 1.2 kW output power and 760 V regulated output voltage with 80-200 V input voltage variations is simulated. The output voltage is regulated by using asymmetric pulse width modulation (APWM) at 200 kHz switching frequency. Finally, a 700-W prototype has been implemented and experimental results are also presented to verify the simulation results.